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39 The results of these studies can provide new information regarding new active compounds that may also be active orally and could be candidates for development as new herapeutic agents for poxvirus infections. In this series of studies, we rst determined the activity of a variety of CDV (HPMPC) analogues (Table 14.6). CDV, cyclic CDV (cHPMPC), and 2(butyl-oxycarbonyl) phenyl cHPMPC had similar 50% effective concentration (EC50) and SI values for both VV and CV in HFF cells. As indicated from previous studies,15,43 S-HPMPA was active against VV and, as determined in our studies, was also effective against CV and was the most active compound in this series. Both (phenethyl L-alaninyl) cHPMPC (mixture of diastereomers) and (butyl L-alaninyl) cHPMPC were ve- to sevenfold more active than HPMPC. In the PMEA series, PMEA itself was not active against VV or CV, but an orally active prodrug, bis[(pivaloyl)oxymethyl] PMEA (adefovir dipivoxil), was very active as was bis(butyl L-alaninyl) PMEA, with EC50 values of 4.4 13 mM. Similarly, the 2,6diaminopurine analogue of PMEA (PMEDAP) was inactive, whereas all the prodrugs were ef cacious against VV, but less active against CV. Antiviral activity was greatest for bis(butyl L-alaninyl) PME-N6-(cyclopropyl)DAP and (isopropyl L-alaninyl) phenyl PME-N6-(cyclopropyl)DAP. Not unexpectedly, the compounds with the best antiviral activities were generally the most toxic. PMPA and its oral prodrug tenofovir disoproxil fumarate {bis[(isopropoxycarbonyl). Print EAN / UCC - 14 In .NET Framework Using Barcode generator for ASP.NET Control to .Related: 

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The purpose of this chapter is to review recent progress in the development of new gents or modi cation of existing compounds such as CDV for orthopoxvirus infections. The chapter is organized somewhat into nucleoside analogues, cidofovir, nucleoside phosphonate analogues, and the ether lipid ester prodrugs of cidofovir. QR Code 2d Barcode Generator In C#.NET Using Barcode drawer for .NET Control to .Related: 

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tidbits that you missed before" Toolbox Gary Bushey .Figure 29-6 The (CMS) is fast becoming a vital content-management tool that Content Management Server new DropDownPlaceholderControl in our VSNET helps administrators and developers handle the ever-increasing amount of content on their Web sites However, an authoritative source of product information has been issing until now. Encoder In .NET Framework Using Barcode maker for ASP .Related: QR Code Generator ASP.NET , Code 39 Generation .NET WinForms , Data Matrix Creating Java

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In Listing 29-4 we're creating the authoring view of the placeholder The first few lines of the function simply create the drop-down list In this example, BOTS only had four industry options, so there are only four "ma add statements We're turning off the view state for the drop-down list control, because when switching be Edit and authoring modes, controls sometimes become "confused" and throw an keep "This is one of those rare books that you will read to learn about the product andexception In the last statement, we're adding our drop-down list control to the authoring environment container Without this rereading to find those tidbits that you missed before" statement, your control(s) Server MVP Gary Bushey, SharePoint won't render (as we found out the first time we created a custom placeholder) Now that we have this much (CMS) is fast we should vital content-management tool by adding it to a Content Management Server of the control,becoming abe able to test the basic control that template To add this new placeholder control to your template, you first should add it to your Toolbox in helps administrators and developers handle the ever-increasing amount of content on their VSNET Adding this an placeholder source Toolbox is pretty easy; just use missing instructions: Web sites However, newauthoritative to your of product information has been the ollowinguntil now.

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Microsoft Content Management Server 2002: A Complete Guide is the first book that explains 1 Open a template and make sure you're in Design view how to effectively unlock the power of CMS Administrators and developers alike will learn how to enhance their Web servers' scalability, flexibility, and extensibility by using CMS features and 2 Once the template appears, click the Content Management Server tab in the VSNET Toolbox You sho API to manage content on the Microsoft platform see the existing placeholder objects that are standard to CMS This thorough reference explains the product architecture, then shows you how to create and 3 Right-click the Toolbox and pick Customize Toolbox from the context menu edit content and use the workflow Topic coverage includes CMS administration and security, the Publishing API, deployment options, site configuration, and template development A tab 4 When the Customize Toolbox dialog appears click the NET Framework Components running example is used throughout the book to illustrate how important CMS features are implemented in real-world Web site development Inside you'll find answers to such will be above the 5 Click the Browse button in the lower right corner of the dialog box; the button questions as: OK/Cancel/Reset/Help buttons.

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